Cutaneous lymphomas in Taiwan: A review of 118 cases from a medical center in southern Taiwan

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Abstract

Background: Cutaneous lymphomas (CLs) have not been well characterized in Taiwan. Methods: We retrospectively reviewed the clinical and pathologic findings of cases of CLs of our department diagnosed from January 2001 to December 2010. The final diagnosis was made according to the 2008 World Health Organization (WHO) classification and its 2016 update. Results: Our series consisted of 91 primary CLs, 27 secondary CLs. The primary CLs consisted of 84 cases of mature T-cell and NK-cell lymphomas (CTCLs) and 7 cases of B-cell lymphomas, including mycosis fungoides (MF) (57.1%), lymphomatoid papulosis (LyP) (14.3%), anaplastic large cell lymphoma (7.7%), extranodal NK/T cell lymphoma, nasal type (4.4%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (3.3%), and diffuse large B-cell lymphoma (4.4%). Most MF (82.6%) cases were early MF (stage I–IIA) and were treated successfully, mainly with ultraviolet B (UVB) 311. The overall 5-year survival rate was 90.7% for early stage MF, 37.5% for stage late MF and 74.9% for all MF cases. Conclusion: Compared to other larger Western and Asian series of primary CLs, our series showed higher proportions of CTCLs and MF. Over 80% of MF was early MF, a finding consistent with the trend in early diagnosis of MF in recent decades. A nation-wide study is warranted to further characterize CLs in Taiwan.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalDermatologica Sinica
Volume36
Issue number1
DOIs
Publication statusPublished - 2018 Mar 1

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Mycosis Fungoides
Taiwan
Lymphoma
Skin
Extranodal NK-T-Cell Lymphoma
Lymphomatoid Papulosis
Anaplastic Large-Cell Lymphoma
Marginal Zone B-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Natural Killer Cells
Early Diagnosis
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

@article{99e96663c8f047389a7c3beeb63a5ab0,
title = "Cutaneous lymphomas in Taiwan: A review of 118 cases from a medical center in southern Taiwan",
abstract = "Background: Cutaneous lymphomas (CLs) have not been well characterized in Taiwan. Methods: We retrospectively reviewed the clinical and pathologic findings of cases of CLs of our department diagnosed from January 2001 to December 2010. The final diagnosis was made according to the 2008 World Health Organization (WHO) classification and its 2016 update. Results: Our series consisted of 91 primary CLs, 27 secondary CLs. The primary CLs consisted of 84 cases of mature T-cell and NK-cell lymphomas (CTCLs) and 7 cases of B-cell lymphomas, including mycosis fungoides (MF) (57.1{\%}), lymphomatoid papulosis (LyP) (14.3{\%}), anaplastic large cell lymphoma (7.7{\%}), extranodal NK/T cell lymphoma, nasal type (4.4{\%}), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (3.3{\%}), and diffuse large B-cell lymphoma (4.4{\%}). Most MF (82.6{\%}) cases were early MF (stage I–IIA) and were treated successfully, mainly with ultraviolet B (UVB) 311. The overall 5-year survival rate was 90.7{\%} for early stage MF, 37.5{\%} for stage late MF and 74.9{\%} for all MF cases. Conclusion: Compared to other larger Western and Asian series of primary CLs, our series showed higher proportions of CTCLs and MF. Over 80{\%} of MF was early MF, a finding consistent with the trend in early diagnosis of MF in recent decades. A nation-wide study is warranted to further characterize CLs in Taiwan.",
author = "Lee, {Chaw Ning} and Chao-Kai Hsu and Kung-Chao Chang and Wu, {Cheng Lin} and Tsai-Yun Chen and Yu-Yun Lee",
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TY - JOUR

T1 - Cutaneous lymphomas in Taiwan

T2 - A review of 118 cases from a medical center in southern Taiwan

AU - Lee, Chaw Ning

AU - Hsu, Chao-Kai

AU - Chang, Kung-Chao

AU - Wu, Cheng Lin

AU - Chen, Tsai-Yun

AU - Lee, Yu-Yun

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background: Cutaneous lymphomas (CLs) have not been well characterized in Taiwan. Methods: We retrospectively reviewed the clinical and pathologic findings of cases of CLs of our department diagnosed from January 2001 to December 2010. The final diagnosis was made according to the 2008 World Health Organization (WHO) classification and its 2016 update. Results: Our series consisted of 91 primary CLs, 27 secondary CLs. The primary CLs consisted of 84 cases of mature T-cell and NK-cell lymphomas (CTCLs) and 7 cases of B-cell lymphomas, including mycosis fungoides (MF) (57.1%), lymphomatoid papulosis (LyP) (14.3%), anaplastic large cell lymphoma (7.7%), extranodal NK/T cell lymphoma, nasal type (4.4%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (3.3%), and diffuse large B-cell lymphoma (4.4%). Most MF (82.6%) cases were early MF (stage I–IIA) and were treated successfully, mainly with ultraviolet B (UVB) 311. The overall 5-year survival rate was 90.7% for early stage MF, 37.5% for stage late MF and 74.9% for all MF cases. Conclusion: Compared to other larger Western and Asian series of primary CLs, our series showed higher proportions of CTCLs and MF. Over 80% of MF was early MF, a finding consistent with the trend in early diagnosis of MF in recent decades. A nation-wide study is warranted to further characterize CLs in Taiwan.

AB - Background: Cutaneous lymphomas (CLs) have not been well characterized in Taiwan. Methods: We retrospectively reviewed the clinical and pathologic findings of cases of CLs of our department diagnosed from January 2001 to December 2010. The final diagnosis was made according to the 2008 World Health Organization (WHO) classification and its 2016 update. Results: Our series consisted of 91 primary CLs, 27 secondary CLs. The primary CLs consisted of 84 cases of mature T-cell and NK-cell lymphomas (CTCLs) and 7 cases of B-cell lymphomas, including mycosis fungoides (MF) (57.1%), lymphomatoid papulosis (LyP) (14.3%), anaplastic large cell lymphoma (7.7%), extranodal NK/T cell lymphoma, nasal type (4.4%), extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (3.3%), and diffuse large B-cell lymphoma (4.4%). Most MF (82.6%) cases were early MF (stage I–IIA) and were treated successfully, mainly with ultraviolet B (UVB) 311. The overall 5-year survival rate was 90.7% for early stage MF, 37.5% for stage late MF and 74.9% for all MF cases. Conclusion: Compared to other larger Western and Asian series of primary CLs, our series showed higher proportions of CTCLs and MF. Over 80% of MF was early MF, a finding consistent with the trend in early diagnosis of MF in recent decades. A nation-wide study is warranted to further characterize CLs in Taiwan.

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DO - 10.1016/j.dsi.2017.08.004

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JO - Dermatologica Sinica

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