Cyclization reactions of methylthioacetanilides

Yu Jen Liao, Yi Lung Wu, Che Ping Chuang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


The cyclization reactions of methylthioacetanilides mediated by manganese(III) acetate and/or copper(II) acetate are described. Indolinones and indolinediones can be produced effectively via a 5-membered ring cyclization of methylthioacetanilides. The product distributions are highly dependent on the reaction conditions. In most cases, the electronic effect of the substituents on the aryl ring was found to significantly affect the yields of cyclization products. This cyclization reaction proceeded faster with manganese(III) acetate/copper(II) acetate.

Original languageEnglish
Pages (from-to)3511-3520
Number of pages10
Issue number19
Publication statusPublished - 2003 May 5

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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