Cyclodextrin-conjugated nanocarrier for magnetically guided delivery of hydrophobic drugs

Shashwat S. Banerjee, Dong Hwang Chen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A magnetic nanosystem that simultaneously implements the cyclodextrin-drug complexation power, bioadhesive property of gum arabic (GA) and inherent magnetic properties of Fe3O4 nanoparticles, has recently been reported. In this study, a magnetic nanocarrier was fabricated by conjugating 2-hydroxypropyl-cyclodextrin (HCD) onto the gum arabic modified magnetic nanoparticles (GAMNP). The analyses of transmission electron microscopy (TEM) and dynamic light scattering (DLS) revealed that the product had a mean diameter of 14.8 nm and a mean hydrodynamic diameter of 29.3 nm. This nanocarrier showed good loading efficiency for ketoprofen. In addition, the in vitro release profile of ketoprofen from HCD-GAMNP was characterized by an initial fast release followed by a delayed release phase. In view of the better biocompatibility and the combined properties like specific targeting, complexation ability with hydrophobic drugs makes the nanosystem an exciting prospect for drug delivery.

Original languageEnglish
Pages (from-to)2071-2078
Number of pages8
JournalJournal of Nanoparticle Research
Volume11
Issue number8
DOIs
Publication statusPublished - 2009 Nov 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

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