Cystatin C as a predictor for outcomes in patients with negligible renal function

Li Chun Ho, Junne-Ming Sung, Yau-Sheng Tsai, Hsi Hao Wang, Yi Che Li, Yi Ting Chen, Min Yu Chang, Shih Yuan Hung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate the predictive power of CysC in patients with a negligible GFR. Methods: Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement of CysC levels and were followed up for one year. A daily urine amount <100 ml was considered negligible residual renal function (RRF). Results: CysC results were available in 183 dialysis patients. Of these, 131 patients had a negligible RRF. The multivariate Cox proportional hazards model showed that CysC was an independent predictor of fatal and nonfatal cardiovascular and infection events in all dialysis patients and in dialysis patients with a negligible RRF. Conclusion: CysC maintained its predictive power for adverse outcomes in patients with no meaningful GFR, indicating that the prognostic value of CysC is independent of the GFR.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalBlood Purification
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 May 22

Fingerprint

Cystatin C
Kidney
Glomerular Filtration Rate
Dialysis
Cardiovascular Infections
Peritoneal Dialysis
Proportional Hazards Models
Renal Dialysis
Urine
Serum

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

Cite this

Ho, Li Chun ; Sung, Junne-Ming ; Tsai, Yau-Sheng ; Wang, Hsi Hao ; Li, Yi Che ; Chen, Yi Ting ; Chang, Min Yu ; Hung, Shih Yuan. / Cystatin C as a predictor for outcomes in patients with negligible renal function. In: Blood Purification. 2014 ; Vol. 38, No. 2. pp. 81-88.
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abstract = "Background: High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate the predictive power of CysC in patients with a negligible GFR. Methods: Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement of CysC levels and were followed up for one year. A daily urine amount <100 ml was considered negligible residual renal function (RRF). Results: CysC results were available in 183 dialysis patients. Of these, 131 patients had a negligible RRF. The multivariate Cox proportional hazards model showed that CysC was an independent predictor of fatal and nonfatal cardiovascular and infection events in all dialysis patients and in dialysis patients with a negligible RRF. Conclusion: CysC maintained its predictive power for adverse outcomes in patients with no meaningful GFR, indicating that the prognostic value of CysC is independent of the GFR.",
author = "Ho, {Li Chun} and Junne-Ming Sung and Yau-Sheng Tsai and Wang, {Hsi Hao} and Li, {Yi Che} and Chen, {Yi Ting} and Chang, {Min Yu} and Hung, {Shih Yuan}",
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Cystatin C as a predictor for outcomes in patients with negligible renal function. / Ho, Li Chun; Sung, Junne-Ming; Tsai, Yau-Sheng; Wang, Hsi Hao; Li, Yi Che; Chen, Yi Ting; Chang, Min Yu; Hung, Shih Yuan.

In: Blood Purification, Vol. 38, No. 2, 22.05.2014, p. 81-88.

Research output: Contribution to journalArticle

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AU - Ho, Li Chun

AU - Sung, Junne-Ming

AU - Tsai, Yau-Sheng

AU - Wang, Hsi Hao

AU - Li, Yi Che

AU - Chen, Yi Ting

AU - Chang, Min Yu

AU - Hung, Shih Yuan

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AB - Background: High serum cystatin C (CysC) has been associated with clinical risks independently of the glomerular filtration rate (GFR). This study aims to investigate the predictive power of CysC in patients with a negligible GFR. Methods: Patients on chronic hemodialysis or peritoneal dialysis were enrolled for measurement of CysC levels and were followed up for one year. A daily urine amount <100 ml was considered negligible residual renal function (RRF). Results: CysC results were available in 183 dialysis patients. Of these, 131 patients had a negligible RRF. The multivariate Cox proportional hazards model showed that CysC was an independent predictor of fatal and nonfatal cardiovascular and infection events in all dialysis patients and in dialysis patients with a negligible RRF. Conclusion: CysC maintained its predictive power for adverse outcomes in patients with no meaningful GFR, indicating that the prognostic value of CysC is independent of the GFR.

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