Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria

Chung Ren Su, Yune Fang Ueng, Xuan Dung Nguyen, M. Vijaya Bhaskar Reddy, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Four new furanoditerpenoids, fibrauretin A (1), fibrauretinoside A (2), epi-fibrauretinoside A (3), and epi-2-palmatoside G (4), and a new ecdysteroid glucoside, fibraurecdyside A (5), together with seven known compounds including two furanoditerpenoids (6 and 7), an ecdysteroid (8), and four quaternary protoberberine alkaloids (9-12) were isolated from the stems of Fibraurea tinctoria. The structures of 1-5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine (9) and jatrorrhizine (10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC50 values of 0.9 and 2.1 μM, respectively.

Original languageEnglish
Pages (from-to)1930-1933
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number12
DOIs
Publication statusPublished - 2007 Dec 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria'. Together they form a unique fingerprint.

Cite this