TY - JOUR
T1 - Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis
AU - Wu, Tian Shung
AU - Su, Chung Ren
AU - Lee, Kuo Hsiung
PY - 2012/6
Y1 - 2012/6
N2 - Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.
AB - Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.
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U2 - 10.1177/1934578x1200700608
DO - 10.1177/1934578x1200700608
M3 - Article
C2 - 22816292
AN - SCOPUS:84864672629
SN - 1934-578X
VL - 7
SP - 725
EP - 727
JO - Natural Product Communications
JF - Natural Product Communications
IS - 6
ER -