Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis

Tian Shung Wu, Chung Ren Su, Kuo Hsiung Lee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the cytotoxic ethanol extract of Cryptocarya chinensis has led to the isolation of 11 compounds, including two phenanthroindolizidine alkaloids [(-)-antofine (1) and dehydroantofine (2)], five pavine alkaloids (3-7), and four proaporphine alkaloids (8-11). The structures of the isolated compounds were determined by means of NMR spectroscopic methods, and supported by HRMS and optical rotation data. Compounds 1 and 2 showed cytotoxic activity against four cancer cell lines, L1210, P388, A549, and HCT-8, with 1 being the most potent against A549 and HCT-8 with EC50 values of 0.002 and 0.001 μg/mL, respectively. In addition, 2 is first reported to exhibit significant anti-HIV activity.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalNatural Product Communications
Volume7
Issue number6
DOIs
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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