Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis

Pei Lin Wu, Fu Wen Lin, Tian Shung Wu, Chang Sheng Kuoh, Kuo Hsiung Lee, Shiow Ju Lee

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (2)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α- Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number3
DOIs
Publication statusPublished - 2004 Mar

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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