TY - JOUR
T1 - Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis
AU - Wu, Pei Lin
AU - Lin, Fu Wen
AU - Wu, Tian Shung
AU - Kuoh, Chang Sheng
AU - Lee, Kuo Hsiung
AU - Lee, Shiow Ju
PY - 2004/3
Y1 - 2004/3
N2 - Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (2)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α- Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
AB - Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (2)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α- Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
UR - http://www.scopus.com/inward/record.url?scp=4544340410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4544340410&partnerID=8YFLogxK
U2 - 10.1248/cpb.52.345
DO - 10.1248/cpb.52.345
M3 - Article
C2 - 14993759
AN - SCOPUS:4544340410
VL - 52
SP - 345
EP - 349
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 3
ER -