Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis

Pei Lin Wu; Fu Wen Lin; Tian Shung Wu; Chang Sheng Kuoh; Kuo Hsiung Lee; Shiow Ju Lee

doi:10.1248/cpb.52.345

Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis

Pei Lin Wu, Fu Wen Lin, Tian Shung Wu, Chang Sheng Kuoh, Kuo Hsiung Lee, Shiow Ju Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (2)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α- Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.

Original language	English
Pages (from-to)	345-349
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	3
DOIs	https://doi.org/10.1248/cpb.52.345
Publication status	Published - 2004 Mar

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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title = "Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis",

abstract = "Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin I (8), and (2)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3β,22α- Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.",

author = "Wu, {Pei Lin} and Lin, {Fu Wen} and Wu, {Tian Shung} and Kuoh, {Chang Sheng} and Lee, {Kuo Hsiung} and Lee, {Shiow Ju}",

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AU - Lee, Shiow Ju

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