Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

Ping Chung Kuo, Li Shian Shi, Amooru G. Damu, Chung Ren Su, Chieh Hung Huang, Chih Huang Ke, Jin Bin Wu, Ai Jeng Lin, Kenneth F. Bastow, Kuo Hsiung Lee, Tian Shung Wu

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

Original languageEnglish
Pages (from-to)1324-1327
Number of pages4
JournalJournal of Natural Products
Volume66
Issue number10
DOIs
Publication statusPublished - 2003 Oct

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia'. Together they form a unique fingerprint.

  • Cite this

    Kuo, P. C., Shi, L. S., Damu, A. G., Su, C. R., Huang, C. H., Ke, C. H., Wu, J. B., Lin, A. J., Bastow, K. F., Lee, K. H., & Wu, T. S. (2003). Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia. Journal of Natural Products, 66(10), 1324-1327. https://doi.org/10.1021/np030277n