Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

Ping Chung Kuo; Li Shian Shi; Amooru G. Damu; Chung Ren Su; Chieh Hung Huang; Chih Huang Ke; Jin Bin Wu; Ai Jeng Lin; Kenneth F. Bastow; Kuo Hsiung Lee; Tian Shung Wu

doi:10.1021/np030277n

Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

Ping Chung Kuo, Li Shian Shi, Amooru G. Damu, Chung Ren Su, Chieh Hung Huang, Chih Huang Ke, Jin Bin Wu, Ai Jeng Lin, Kenneth F. Bastow, Kuo Hsiung Lee, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Abstract

Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

Original language	English
Pages (from-to)	1324-1327
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	10
DOIs	https://doi.org/10.1021/np030277n
Publication status	Published - 2003 Oct

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np030277n

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@article{e1365258659d4296bb336078f1a38945,

title = "Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia",

abstract = "Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.",

author = "Kuo, {Ping Chung} and Shi, {Li Shian} and Damu, {Amooru G.} and Su, {Chung Ren} and Huang, {Chieh Hung} and Ke, {Chih Huang} and Wu, {Jin Bin} and Lin, {Ai Jeng} and Bastow, {Kenneth F.} and Lee, {Kuo Hsiung} and Wu, {Tian Shung}",

year = "2003",

month = oct,

doi = "10.1021/np030277n",

language = "English",

volume = "66",

pages = "1324--1327",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

AU - Kuo, Ping Chung

AU - Shi, Li Shian

AU - Damu, Amooru G.

AU - Su, Chung Ren

AU - Huang, Chieh Hung

AU - Ke, Chih Huang

AU - Wu, Jin Bin

AU - Lin, Ai Jeng

AU - Bastow, Kenneth F.

AU - Lee, Kuo Hsiung

AU - Wu, Tian Shung

PY - 2003/10

Y1 - 2003/10

N2 - Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

AB - Three new [n-pentyl β-carboline-l-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known β-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

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U2 - 10.1021/np030277n

DO - 10.1021/np030277n

M3 - Article

C2 - 14575431

AN - SCOPUS:10744224152

SN - 0163-3864

VL - 66

SP - 1324

EP - 1327

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Cytotoxic and Antimalarial β-Carboline Alkaloids from the Roots of Eurycoma longifolia

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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