Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

Tian Shung Wu; Meei Jen Liou; Chang Sheng Kuoh; Che Ming Teng; Tsuneatsu Nagao; Kuo Hsiung Lee

doi:10.1021/np970163+

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

Tian Shung Wu, Meei Jen Liou, Chang Sheng Kuoh, Che Ming Teng, Tsuneatsu Nagao, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.

Original language	English
Pages (from-to)	606-608
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	6
DOIs	https://doi.org/10.1021/np970163+
Publication status	Published - 1997 Jun

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np970163+

Cite this

@article{0cd36634713b4e528912a04c10b6b11f,

title = "Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia",

abstract = "Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.",

author = "Wu, {Tian Shung} and Liou, {Meei Jen} and Kuoh, {Chang Sheng} and Teng, {Che Ming} and Tsuneatsu Nagao and Lee, {Kuo Hsiung}",

year = "1997",

month = jun,

doi = "10.1021/np970163+",

language = "English",

volume = "60",

pages = "606--608",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

AU - Wu, Tian Shung

AU - Liou, Meei Jen

AU - Kuoh, Chang Sheng

AU - Teng, Che Ming

AU - Nagao, Tsuneatsu

AU - Lee, Kuo Hsiung

PY - 1997/6

Y1 - 1997/6

N2 - Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.

AB - Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 μM and 2 ng/mL, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0030920525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030920525&partnerID=8YFLogxK

U2 - 10.1021/np970163+

DO - 10.1021/np970163+

M3 - Article

C2 - 9214732

AN - SCOPUS:0030920525

SN - 0163-3864

VL - 60

SP - 606

EP - 608

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 6

ER -

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this