Cytotoxic and antiplatelet aggregation principles of Ruta graveolens

Tian Shung Wu, Li Shian Shi, Jhi Joung Wang, Song Chou Iou, Hsien Chang Chang, Yuh Pan Chen, Yao Haur Kuo, Ya Ling Chang, Che Ming Teng

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Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens. The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine (5), skimmianine (7), psoralen (8), chalepensin (12), clausindin (13), and graveolinine (16) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine (2), dictamine (5), isopimpinellin (11), clausindin (13), and graveoline (17) exhibited cytotoxic activity against KB, Hela, DLD, NCI and Hepa tumor cell lines.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalJournal of the Chinese Chemical Society
Issue number1
Publication statusPublished - 2003 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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