Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien, Jang-Yang Chang, Ching Chuan Kuo, Cheng Chih Hsieh, Ning Sun Yang, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.0 2.6 ]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC 50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

Original languageEnglish
Pages (from-to)1567-1569
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number9
DOIs
Publication statusPublished - 2007 Feb 26

Fingerprint

Chamaecyparis
Monoterpenes
Skeleton
Cells
Neoplasms
chamaecypanone C
undecane

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Chien, Shih Chang ; Chang, Jang-Yang ; Kuo, Ching Chuan ; Hsieh, Cheng Chih ; Yang, Ning Sun ; Kuo, Yueh Hsiung. / Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 9. pp. 1567-1569.
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Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana. / Chien, Shih Chang; Chang, Jang-Yang; Kuo, Ching Chuan; Hsieh, Cheng Chih; Yang, Ning Sun; Kuo, Yueh Hsiung.

In: Tetrahedron Letters, Vol. 48, No. 9, 26.02.2007, p. 1567-1569.

Research output: Contribution to journalArticle

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