Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana

Shih Chang Chien, Jang Yang Chang, Ching Chuan Kuo, Cheng Chih Hsieh, Ning Sun Yang, Yueh Hsiung Kuo

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26 Citations (Scopus)

Abstract

The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.

Original languageEnglish
Pages (from-to)1567-1569
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number9
DOIs
Publication statusPublished - 2007 Feb 26

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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