Cytotoxic anthraquinones from the stems of Rubia wallichiana DECNE

Tian Shung Wu, Dau Min Lin, Li Shian Shi, Amooru Gangaiah Damu, Ping Chung Kuo, Yao Hau Kuo

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

From the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their structures were determined by comprehensive analyses of their 1D and 2D NMR, and electron impact (EI) mass spectral data. Furthermore, an in vitro screening of cytotoxicity of the isolated compounds was also evaluated. Among the testing compounds, 1-hydroxy-2-hydroxymethyl-3- methoxyanthraquinone (4) demonstrated most effective cytotoxicity towards Hepa-3B and Colo-205 cells.

Original languageEnglish
Pages (from-to)948-950
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number8
DOIs
Publication statusPublished - 2003 Aug

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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