Cytotoxic C35 terpenoid cryptotrione from the bark of cryptomeria japonica

Cheng Chi Chen, Jyh Horng Wu, Ning Sun Yang, Jang Yang Chang, Ching Chuan Kuo, Sheng Yang Wang, Yueh Hsiung Kuo

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

(Figure presented) A novel C35-terpene, designated as cryptotrione (1), with an unprecedented skeleton possessing an abietane diterpene with a unique bicyclic sesquiterpene, is identified from the bark of Cryptomeria japonica. The carbon skeleton of 1 represents a new structural entity, and this is an intriguing addition to the structurally diverse diterpene-sesquiterpene class. A unique biosynthetic pathway is proposed to support the production of this phytocompound. Notably, 1 exhibits anticancer activity with an IC50 value of 6.44 ± 2.23 μM.

Original languageEnglish
Pages (from-to)2786-2789
Number of pages4
JournalOrganic Letters
Volume12
Issue number12
DOIs
Publication statusPublished - 2010 Jun 18

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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