Cytotoxic phenanthroindolizidine alkaloids from the roots of ficus septica

Amooru F. Damu, Ping-Chung Kuo, Li Shian Shi, Chia Ying Li, Chung Ren Su, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids, including ten new ficuseptines E-N (1-10) and ten known compounds. The cytotoxic effects of some of the isolateswere tested on gastric adenocarcinoma (NUGC) and nasopharyngeal carcinoma (HONE-1) cell lines and the results demonstrated that, with the exception of dehydrotylophorine, all the tested compounds displayed pronounced cytotoxic activity with significant cell growth inhibitory effects. In addition, 13aR-antofine was found to be highly effective with ED50 values of < 0.1 μg/mL against L-1210, P-388, A- 549 and HCT-8 cell lines in another assay.

Original languageEnglish
Pages (from-to)1152-1156
Number of pages5
JournalPlanta Medica
Volume75
Issue number10
DOIs
Publication statusPublished - 2009 Nov 11

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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