Cytotoxic principles from the leaves of Tithonia diversifolia

Tian-Shung Wu, Li Shian Shi, Ping-Chung Kuo, Yann Lii Leu, Meei Jen Liou, Pei Lin Wu, Yang Chang Wu, Song Chou Iou, Yuh Pan Chen, Hsien-Chang Chang

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10 Citations (Scopus)

Abstract

Three compounds, acetyltagitinin E (1), tagitinin-F (2) and hispidulin (3), were isolated from the leaves of Tithonia diversifolia. The stereochemistry of 1 was further supported by X-ray crystallography. The cytotoxicity of these compounds was also determined. Compounds 1 and 2 showed selective cytotoxicity to Hep G2 human hepatocellular carcinoma cells.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalChinese Pharmaceutical Journal
Volume53
Issue number5
Publication statusPublished - 2001 Dec 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Wu, T-S., Shi, L. S., Kuo, P-C., Leu, Y. L., Liou, M. J., Wu, P. L., Wu, Y. C., Iou, S. C., Chen, Y. P., & Chang, H-C. (2001). Cytotoxic principles from the leaves of Tithonia diversifolia. Chinese Pharmaceutical Journal, 53(5), 217-223.