Cytotoxicity of Ganoderma lucidum triterpenes

Tian-Shung Wu; L. S. Shi; S. C. Kuo

doi:10.1021/np010115w

Cytotoxicity of Ganoderma lucidum triterpenes

Tian-Shung Wu, L. S. Shi, S. C. Kuo

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.

Original language	English
Pages (from-to)	1121-1122
Number of pages	2
Journal	Journal of Natural Products
Volume	64
Issue number	8
DOIs	https://doi.org/10.1021/np010115w
Publication status	Published - 2001 Sept 11

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np010115w

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title = "Cytotoxicity of Ganoderma lucidum triterpenes",

abstract = "Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.",

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AU - Shi, L. S.

AU - Kuo, S. C.

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N2 - Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.

AB - Two new triterpenoids, lucidenic acid N (1) and methyl lucidenate F (2), together with four known compounds, lucidenic acid A, lucidenolactone, lucidenic acid C, and ganoderic acid E, were isolated from the dried fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectral and chemical transformation studies. Among them, lucidenic acid N (1), lucidenic acid A, and ganoderic acid E showed significant cytotoxic activity against Hep G2, Hep G2,2,15, and P-388 tumor cells.

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JO - Journal of Natural Products

JF - Journal of Natural Products

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Cytotoxicity of Ganoderma lucidum triterpenes

Abstract

All Science Journal Classification (ASJC) codes

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