Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis

Pei Lin Wu, Ta Hsien Chuang, Cai Xia He, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9-O-feruloyl-(-) -secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9μg/mL, respectively.

Original languageEnglish
Pages (from-to)2193-2197
Number of pages5
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number9
DOIs
Publication statusPublished - 2004 May 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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