Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis

Pei Lin Wu, Ta Hsien Chuang, Cai Xia He, Tian Shung Wu

Research output: Contribution to journalArticle

27 Citations (Scopus)


The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9-O-feruloyl-(-) -secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9μg/mL, respectively.

Original languageEnglish
Pages (from-to)2193-2197
Number of pages5
JournalBioorganic and Medicinal Chemistry
Issue number9
Publication statusPublished - 2004 May 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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