TY - JOUR
T1 - Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis
AU - Wu, Pei Lin
AU - Chuang, Ta Hsien
AU - He, Cai Xia
AU - Wu, Tian Shung
N1 - Funding Information:
The authors would like to thank the National Science Council of the Republic of China for the financial support (NSC 90-2323-B-006-003). We also thank Prof. Kuo-Hsiung Lee, Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, USA, for the cytotoxicity and anti-HIV assays.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9′-O-feruloyl-(-) -secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9μg/mL, respectively.
AB - The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9′-O-feruloyl-(-) -secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9μg/mL, respectively.
UR - https://www.scopus.com/pages/publications/1842636253
UR - https://www.scopus.com/pages/publications/1842636253#tab=citedBy
U2 - 10.1016/j.bmc.2004.02.020
DO - 10.1016/j.bmc.2004.02.020
M3 - Article
C2 - 15080919
AN - SCOPUS:1842636253
SN - 0968-0896
VL - 12
SP - 2193
EP - 2197
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 9
ER -