Daily life events influence the results of the dexamethasone suppression test in healthy women

Wei Tseng Chen; Tzung Lieh Yeh; Venla Lehti; Shu Hui Cheng; Ching Lin Chu; Kao Chin Chen; I. Hui Lee; Po See Chen; Yen Kuang Yang

doi:10.1080/08964289.2012.679327

Daily life events influence the results of the dexamethasone suppression test in healthy women

Wei Tseng Chen, Tzung Lieh Yeh, Venla Lehti, Shu Hui Cheng, Ching Lin Chu, Kao Chin Chen, I. Hui Lee, Po See Chen, Yen Kuang Yang

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Although the Dexamethasone Suppression Test (DST) plays an important role in psychosomatic research, confounding factors limit the sensitivity and specificity of the DST. The aim of this study was to investigate the relationship between the intensity of daily life stressors and DST results in healthy participants after controlling the confounding factors. The subjects of this study consisted of 75 healthy volunteers. The intensity of daily life events was assessed using the Taiwanese version of the Recent Life Change Questionnaire (RLCQ). Neuroticism was assessed using the Maudsley Personality Inventory (MPI). The Dexamethasone Suppression Test (DST) was also performed. The regression model showed that daily life events (RLCQ score) were correlated significantly with cortisol level on day 1 and D% only in women. This finding implies that daily life events should be considered as an independent variable in women in further studies when the DST is applied.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Behavioral Medicine
Volume	38
Issue number	2
DOIs	https://doi.org/10.1080/08964289.2012.679327
Publication status	Published - 2012 Apr 1

All Science Journal Classification (ASJC) codes

Applied Psychology
Psychiatry and Mental health

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10.1080/08964289.2012.679327

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title = "Daily life events influence the results of the dexamethasone suppression test in healthy women",

abstract = "Although the Dexamethasone Suppression Test (DST) plays an important role in psychosomatic research, confounding factors limit the sensitivity and specificity of the DST. The aim of this study was to investigate the relationship between the intensity of daily life stressors and DST results in healthy participants after controlling the confounding factors. The subjects of this study consisted of 75 healthy volunteers. The intensity of daily life events was assessed using the Taiwanese version of the Recent Life Change Questionnaire (RLCQ). Neuroticism was assessed using the Maudsley Personality Inventory (MPI). The Dexamethasone Suppression Test (DST) was also performed. The regression model showed that daily life events (RLCQ score) were correlated significantly with cortisol level on day 1 and D% only in women. This finding implies that daily life events should be considered as an independent variable in women in further studies when the DST is applied.",

author = "Chen, {Wei Tseng} and Yeh, {Tzung Lieh} and Venla Lehti and Cheng, {Shu Hui} and Chu, {Ching Lin} and Chen, {Kao Chin} and Lee, {I. Hui} and Chen, {Po See} and Yang, {Yen Kuang}",

note = "Funding Information: The authors gratefully acknowledge the financial support from the National Science Council of Taiwan (NSC 93-2314-B-006-107, 97-2314-B-006-006-MY3) and the administrative support of Misses Tsai-Hua Chang, Yi Wen Chen, Yun-Hsuan Chang, and Mr. Chien Ting Lin. All authors declare that they have no conflict of interest. The funding institutions of this study had no further role in the study design; the collection, analysis and interpretation of data; the writing of the report; or the decision to submit the paper for publication.",

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AU - Chen, Kao Chin

AU - Lee, I. Hui

AU - Chen, Po See

AU - Yang, Yen Kuang

N1 - Funding Information: The authors gratefully acknowledge the financial support from the National Science Council of Taiwan (NSC 93-2314-B-006-107, 97-2314-B-006-006-MY3) and the administrative support of Misses Tsai-Hua Chang, Yi Wen Chen, Yun-Hsuan Chang, and Mr. Chien Ting Lin. All authors declare that they have no conflict of interest. The funding institutions of this study had no further role in the study design; the collection, analysis and interpretation of data; the writing of the report; or the decision to submit the paper for publication.

PY - 2012/4/1

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Daily life events influence the results of the dexamethasone suppression test in healthy women

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