Dang-Gui-Bu-Xai-Tang modulated the immunity of tumor bearing mice

Chang Chi Hsieh, Wen Chang Lin, Miau Rong Lee, Shih Lan Hsu, Hsiao Sheng Liu, Shung Te Kao, Ming Tsuen Hsieh

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Dang-Gui-Bu-Xai-Tang (DGBXT), which includes Radix Angelicae Sinensis and Radix Astragali Membranaceus, is a traditional Chinese medicine used to modulate the lymphocyte activity of cancer patients after chemotherapy and radiotherapy. In the present study, we examined the cytotoxicity of DGBXT on transformed cells and the immunomodulating effects of DGBXT in a tumor-bearing murine model. DGBXT markedly inhibited the growth of the EJ-Ha-ras transformed LZEJ and LZEJ-C2 cells lines. Oral administration of DGBXT for three weeks significantly prevented the tumor development in mice that injected with LZEJ-C2 cells subcutaneously. Moreover, DGBXT effectively increased the population of cytotoxic T lymphocytes (CTLs) and NK cells, and down-regulated activated T helper cells (CD4+/CD25+) in spleen and tumor-draining lymph nodes (TDLN). Furthermore, DGBXT stimulated the production of tumor necrosis factor-α in in vitro cultured splenocytes. These results might explain the antitumor effects of DGBXT.

Original languageEnglish
Pages (from-to)259-271
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Volume25
Issue number2
DOIs
Publication statusPublished - 2003

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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