Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization

H. M. Shih, C. C. Chang, H. Y. Kuo, Ding-Yen Lin

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding protein)-binding protein] co-activator results in the recruitment of a transcriptional co-repressor Daxx, thereby causing transcriptional repression. Such a SUMO-dependent recruitment of Daxx is mediated by the interaction between the SUMO moiety of SUMOylated factors and Daxx SUMO-interacting motif. Interestingly, the transrepression effect of Daxx on these SUMOylated transcription factors can be relieved by SUMOylated PML (promyelocytic leukaemia) via altering Daxx partition from the targeted gene promoter to PML nuclear bodies. Because Daxx SUMO-interacting motif is a common binding site for SUMOylated factors, a model of competition for Daxx recruitment between SUMOylated PML and SUMOylated transcription factors was proposed. Together, our findings strongly suggest that Daxx functions as a SUMO reader in the SUMO-dependent regulation of transcription and subnuclear compartmentalization.

Original languageEnglish
Pages (from-to)1397-1400
Number of pages4
JournalBiochemical Society Transactions
Volume35
Issue number6
DOIs
Publication statusPublished - 2007 Dec 1

Fingerprint

Ubiquitin
Transcription Factors
Leukemia
Transcription
Sumoylation
Cyclic AMP Response Element-Binding Protein
Co-Repressor Proteins
Glucocorticoid Receptors
Androgen Receptors
Protein Binding
Carrier Proteins
Genes
Binding Sites

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

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abstract = "SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding protein)-binding protein] co-activator results in the recruitment of a transcriptional co-repressor Daxx, thereby causing transcriptional repression. Such a SUMO-dependent recruitment of Daxx is mediated by the interaction between the SUMO moiety of SUMOylated factors and Daxx SUMO-interacting motif. Interestingly, the transrepression effect of Daxx on these SUMOylated transcription factors can be relieved by SUMOylated PML (promyelocytic leukaemia) via altering Daxx partition from the targeted gene promoter to PML nuclear bodies. Because Daxx SUMO-interacting motif is a common binding site for SUMOylated factors, a model of competition for Daxx recruitment between SUMOylated PML and SUMOylated transcription factors was proposed. Together, our findings strongly suggest that Daxx functions as a SUMO reader in the SUMO-dependent regulation of transcription and subnuclear compartmentalization.",
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Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization. / Shih, H. M.; Chang, C. C.; Kuo, H. Y.; Lin, Ding-Yen.

In: Biochemical Society Transactions, Vol. 35, No. 6, 01.12.2007, p. 1397-1400.

Research output: Contribution to journalArticle

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