Deciphering laminar-specific neural inputs with line-scanning fMRI

Xin Yu; Chunqi Qian; Der Yow Chen; Stephen J. Dodd; Alan P. Koretsky

doi:10.1038/nmeth.2730

Deciphering laminar-specific neural inputs with line-scanning fMRI

Xin Yu
, Chunqi Qian
, Der Yow Chen
, Stephen J. Dodd
, Alan P. Koretsky

Department of Psychology

Research output: Contribution to journal › Article › peer-review

137 Citations (Scopus)

Abstract

Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-I 1/4m) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Nature Methods
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/nmeth.2730
Publication status	Published - 2014

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Molecular Biology
Cell Biology

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10.1038/nmeth.2730

Cite this

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abstract = "Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-I 1/4m) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.",

author = "Xin Yu and Chunqi Qian and Chen, \{Der Yow\} and Dodd, \{Stephen J.\} and Koretsky, \{Alan P.\}",

note = "Funding Information: This research was supported by the Intramural Research Program of the US National Institutes of Health–NINDS. We thank K. Sharer and N. Bouraoud for technical support.",

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AU - Dodd, Stephen J.

AU - Koretsky, Alan P.

N1 - Funding Information: This research was supported by the Intramural Research Program of the US National Institutes of Health–NINDS. We thank K. Sharer and N. Bouraoud for technical support.

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N2 - Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-I 1/4m) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.

AB - Using a line-scanning method during functional magnetic resonance imaging (fMRI), we obtained high temporal (50-ms) and spatial (50-I 1/4m) resolution information along the cortical thickness and showed that the laminar position of fMRI onset coincides with distinct neural inputs in rat somatosensory and motor cortices. This laminar-specific fMRI onset allowed us to identify the neural inputs underlying ipsilateral fMRI activation in the barrel cortex due to peripheral denervation-induced plasticity.

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JO - Nature Methods

JF - Nature Methods

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ER -

Deciphering laminar-specific neural inputs with line-scanning fMRI

Abstract

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