TY - JOUR
T1 - Decreased pulmonary function in school children in Western Japan after exposures to Asian desert dusts and its association with interleukin-8
AU - Watanabe, Masanari
AU - Noma, Hisashi
AU - Kurai, Jun
AU - Sano, Hiroyuki
AU - Saito, Rumiko
AU - Abe, Satoshi
AU - Kimura, Yutaka
AU - Aiba, Setsuya
AU - Oshimura, Mitsuo
AU - Yamasaki, Akira
AU - Shimizu, Eiji
AU - Guo, How Ran
N1 - Publisher Copyright:
© 2015 Masanari Watanabe et al.
PY - 2015
Y1 - 2015
N2 - The objective of the study was to investigate the influence of Asian dust storms (ADS) on pulmonary function of school children and the relationship of this effect with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children from April to May 2012 and in 384 of these children from March to May 2013. The data were analyzed for an association between ADS events and PEF by linear mixed models. Interleukin-8 transcriptional activity was assessed in THP-G8 cells stimulated by airborne particles collected on ADS days. Seven ADS days were identified: April 23 and 24, 2012; March 8 to 10, 2013; and March 19 and 20, 2013. Changes in PEF after ADS exposure were-8.17 L/min (95% confidence interval,-11.40 to-4.93) in 2012 and-1.17 L/min (-4.07 to 1.74) in 2013, and there was a significant difference between 2012 and 2013. Interleukin-8 transcriptional activity was significantly higher in 2012 at 10.6 ± 2.9-fold compared to 3.7 ± 0.4 in March 8 to 10, 2013, and 2.3 ± 0.2 in March 19 and 20, 2013. The influence of ADS events on pulmonary function of children differs with each ADS event and may be related to interleukin-8 production.
AB - The objective of the study was to investigate the influence of Asian dust storms (ADS) on pulmonary function of school children and the relationship of this effect with interleukin-8. Morning peak expiratory flow (PEF) was measured daily in 399 children from April to May 2012 and in 384 of these children from March to May 2013. The data were analyzed for an association between ADS events and PEF by linear mixed models. Interleukin-8 transcriptional activity was assessed in THP-G8 cells stimulated by airborne particles collected on ADS days. Seven ADS days were identified: April 23 and 24, 2012; March 8 to 10, 2013; and March 19 and 20, 2013. Changes in PEF after ADS exposure were-8.17 L/min (95% confidence interval,-11.40 to-4.93) in 2012 and-1.17 L/min (-4.07 to 1.74) in 2013, and there was a significant difference between 2012 and 2013. Interleukin-8 transcriptional activity was significantly higher in 2012 at 10.6 ± 2.9-fold compared to 3.7 ± 0.4 in March 8 to 10, 2013, and 2.3 ± 0.2 in March 19 and 20, 2013. The influence of ADS events on pulmonary function of children differs with each ADS event and may be related to interleukin-8 production.
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U2 - 10.1155/2015/583293
DO - 10.1155/2015/583293
M3 - Article
C2 - 26060816
AN - SCOPUS:84929377525
SN - 2314-6133
VL - 2015
JO - BioMed research international
JF - BioMed research international
M1 - 583293
ER -