Design and fabrication of 3D-structured contactless capacitive-type detector for capillary electrophoresis microchip

Chia Yen Lee, Che Hsin Lin, Lung Ming Fu

Research output: Contribution to journalArticle

Abstract

Using simple and reliable microfabrication techniques, this study develops a capillary electrophoresis (CE) microchip with 3-dimensional-structured (3D-structured) contactless capacitive detector electrodes mounted parallel to the separation channel. The offchannel electrodes are deposited by Au sputtering and patterned using a standard 'lift-off process. A vacuum fusion bonding process is employed to seal the lower substrate containing the microchannels and electrodes to an upper glass cover plate. The variation in the capacitance between the electrodes in the side channels is measured as different samples and ions pass through the detection region of the CE separation channel. Samples of Rhodamine B and a commercial sports drink are mixed in different buffer solutions and successfully separated and detected using the developed device. The 3D-structured contactless capacitive-type detection device has microscale dimensions and provides a valuable contribution to the realization of the lab-on-a-chip concept.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalJournal of Physics: Conference Series
Volume34
Issue number1
DOIs
Publication statusPublished - 2006 Apr 1

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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