Design and synthesis of 3-aryl-5-alicylic-[1,2,4]-oxadiazoles as novel platelet aggregation inhibitors

Ching Yuh Chern, Shinn Jyh Chen, Wai Ming Kan

Research output: Contribution to journalArticlepeer-review

Abstract

A series of 4-[2-(alicyclic-[1,2,4]oxadiazol-3-yl)phenoxy]-butyric acids were synthesized from N-hydroxy-2-isopropoxy benzamidine in 4 steps with good yields. These [1,2,4]oxadiazoles are novel platelet aggregation inhibitors preventing human platelet aggregation induced by thromboxane derivative U44,619 and adenosine diphosphate. A structure-activity-relationship study revealed that the potency for these 5-oxadiazoles increases with the increase in the ring size of the alicylic rings. Derivative 8f may be useful as a template for the design of more potent anti-platelet agents.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume52
Issue number2
DOIs
Publication statusPublished - 2005 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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