Abstract
A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.
| Original language | English |
|---|---|
| Pages (from-to) | 9793-9796 |
| Number of pages | 4 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 12 |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - 2014 Dec 28 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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