Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su, Yu Ting Huang, Chang Shi Chen, Hao Chieh Chiu, Chung Wai Shiau

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

Original languageEnglish
Article number27
JournalMolecules
Volume23
Issue number1
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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