Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus

Jung Chen Su, Yu Ting Huang, Chang Shi Chen, Hao Chieh Chiu, Chung Wai Shiau

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.

Original languageEnglish
Article number27
JournalMolecules
Volume23
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Methicillin
staphylococcus
antibiotics
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
Derivatives
Lactams
biofilms
Biofilms
synthesis
toxicity
Toxicity
drugs
cells
Pharmaceutical Preparations
malonamide

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Su, Jung Chen ; Huang, Yu Ting ; Chen, Chang Shi ; Chiu, Hao Chieh ; Shiau, Chung Wai. / Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus. In: Molecules. 2018 ; Vol. 23, No. 1.
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Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus. / Su, Jung Chen; Huang, Yu Ting; Chen, Chang Shi; Chiu, Hao Chieh; Shiau, Chung Wai.

In: Molecules, Vol. 23, No. 1, 27, 01.01.2018.

Research output: Contribution to journalArticle

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