Design and synthesis of new cationic water-soluble pyrene containing dendrons for DNA sensory applications

Ching Yi Chen; Yumiko Ito; Yu Cheng Chiu; Wen Chung Wu; Tomoya Higashihara; Mitsuru Ueda; Wen Chang Chen

doi:10.1002/pola.25031

Design and synthesis of new cationic water-soluble pyrene containing dendrons for DNA sensory applications

Ching Yi Chen, Yumiko Ito, Yu Cheng Chiu, Wen Chung Wu, Tomoya Higashihara, Mitsuru Ueda, Wen Chang Chen

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A series of new water-soluble cationic pyrene-dendron derivatives, G1, G2, and G3, was successfully synthesized and characterized. These new dendrons were designed with the quaternized amino moieties at the periphery of the dendrons for DNA detection and functionalized with pyrene as a fluorescent probe. The electrostatic interactions between the plasmid DNA (pDNA) and cationic charged dendrons in an aqueous solution resulted in a change in the photophysical properties of pyrene, which could be shown in the UV-vis and fluorescence spectra. Pyrene dendrons showed a high and rapid fluorescence response upon the addition of pDNA, which was strongly dependent on the size and hydrophobicity of the dendrons.

Original language	English
Pages (from-to)	297-305
Number of pages	9
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	50
Issue number	2
DOIs	https://doi.org/10.1002/pola.25031
Publication status	Published - 2012 Jan 15

All Science Journal Classification (ASJC) codes

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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abstract = "A series of new water-soluble cationic pyrene-dendron derivatives, G1, G2, and G3, was successfully synthesized and characterized. These new dendrons were designed with the quaternized amino moieties at the periphery of the dendrons for DNA detection and functionalized with pyrene as a fluorescent probe. The electrostatic interactions between the plasmid DNA (pDNA) and cationic charged dendrons in an aqueous solution resulted in a change in the photophysical properties of pyrene, which could be shown in the UV-vis and fluorescence spectra. Pyrene dendrons showed a high and rapid fluorescence response upon the addition of pDNA, which was strongly dependent on the size and hydrophobicity of the dendrons.",

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AU - Chen, Ching Yi

AU - Ito, Yumiko

AU - Chiu, Yu Cheng

AU - Wu, Wen Chung

AU - Higashihara, Tomoya

AU - Ueda, Mitsuru

AU - Chen, Wen Chang

PY - 2012/1/15

Y1 - 2012/1/15

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AB - A series of new water-soluble cationic pyrene-dendron derivatives, G1, G2, and G3, was successfully synthesized and characterized. These new dendrons were designed with the quaternized amino moieties at the periphery of the dendrons for DNA detection and functionalized with pyrene as a fluorescent probe. The electrostatic interactions between the plasmid DNA (pDNA) and cationic charged dendrons in an aqueous solution resulted in a change in the photophysical properties of pyrene, which could be shown in the UV-vis and fluorescence spectra. Pyrene dendrons showed a high and rapid fluorescence response upon the addition of pDNA, which was strongly dependent on the size and hydrophobicity of the dendrons.

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Design and synthesis of new cationic water-soluble pyrene containing dendrons for DNA sensory applications

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