Design of a signal processing circuit for quartz crystal microbalance biosensors

Shih Chang Chang, I. Jen Chao, Bin Da Liu, Chun Yueh Huang, Mei Hwa Lee, Hung Yin Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this paper, we design a signal processing circuit for quartz crystal microbalance (QCM) biosensors. The proposed signal processing circuit, which consists of two oscillators, a mixer, a low-pass filter, can be used to measure small amount of QCM biosensors' frequency variation at a fundamental resonance frequency. Based on the principle of heterodyne technique, the QCM biosensors' frequency variation can be converted into the low frequency composition by a second-order low-pass filter. The output of the low-pass filter is digitized to a stream of digital pulses by a simple digital buffer which represents the corresponding QCM biosensor's frequency variation. The proposed signal processing circuit is implemented by 0.35-μm CMOS technology, and the chip layout area is 1060 mm 2. In the proposed circuit, the maximum range of the detectable frequency variation is 26 kHz under the resolution of 0.5 Hz. In system verification, the proposed signal processing circuit chip is successfully applied in the signal processing of α-Amylase QCM biosensors to detect the change of low concentration biomolecular.

Original languageEnglish
Title of host publicationProceedings - 2011 IEEE 9th International Conference on ASIC, ASICON 2011
Pages180-183
Number of pages4
DOIs
Publication statusPublished - 2011 Dec 1
Event2011 IEEE 9th International Conference on ASIC, ASICON 2011 - Xiamen, China
Duration: 2011 Oct 252011 Oct 28

Publication series

NameProceedings of International Conference on ASIC
ISSN (Print)2162-7541
ISSN (Electronic)2162-755X

Other

Other2011 IEEE 9th International Conference on ASIC, ASICON 2011
CountryChina
CityXiamen
Period11-10-2511-10-28

All Science Journal Classification (ASJC) codes

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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