TY - GEN
T1 - Design of a signal processing circuit for quartz crystal microbalance biosensors
AU - Chang, Shih Chang
AU - Chao, I. Jen
AU - Liu, Bin Da
AU - Huang, Chun Yueh
AU - Lee, Mei Hwa
AU - Lin, Hung Yin
PY - 2011/12/1
Y1 - 2011/12/1
N2 - In this paper, we design a signal processing circuit for quartz crystal microbalance (QCM) biosensors. The proposed signal processing circuit, which consists of two oscillators, a mixer, a low-pass filter, can be used to measure small amount of QCM biosensors' frequency variation at a fundamental resonance frequency. Based on the principle of heterodyne technique, the QCM biosensors' frequency variation can be converted into the low frequency composition by a second-order low-pass filter. The output of the low-pass filter is digitized to a stream of digital pulses by a simple digital buffer which represents the corresponding QCM biosensor's frequency variation. The proposed signal processing circuit is implemented by 0.35-μm CMOS technology, and the chip layout area is 1060 mm 2. In the proposed circuit, the maximum range of the detectable frequency variation is 26 kHz under the resolution of 0.5 Hz. In system verification, the proposed signal processing circuit chip is successfully applied in the signal processing of α-Amylase QCM biosensors to detect the change of low concentration biomolecular.
AB - In this paper, we design a signal processing circuit for quartz crystal microbalance (QCM) biosensors. The proposed signal processing circuit, which consists of two oscillators, a mixer, a low-pass filter, can be used to measure small amount of QCM biosensors' frequency variation at a fundamental resonance frequency. Based on the principle of heterodyne technique, the QCM biosensors' frequency variation can be converted into the low frequency composition by a second-order low-pass filter. The output of the low-pass filter is digitized to a stream of digital pulses by a simple digital buffer which represents the corresponding QCM biosensor's frequency variation. The proposed signal processing circuit is implemented by 0.35-μm CMOS technology, and the chip layout area is 1060 mm 2. In the proposed circuit, the maximum range of the detectable frequency variation is 26 kHz under the resolution of 0.5 Hz. In system verification, the proposed signal processing circuit chip is successfully applied in the signal processing of α-Amylase QCM biosensors to detect the change of low concentration biomolecular.
UR - http://www.scopus.com/inward/record.url?scp=84860865698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860865698&partnerID=8YFLogxK
U2 - 10.1109/ASICON.2011.6157151
DO - 10.1109/ASICON.2011.6157151
M3 - Conference contribution
AN - SCOPUS:84860865698
SN - 9781612841908
T3 - Proceedings of International Conference on ASIC
SP - 180
EP - 183
BT - Proceedings - 2011 IEEE 9th International Conference on ASIC, ASICON 2011
T2 - 2011 IEEE 9th International Conference on ASIC, ASICON 2011
Y2 - 25 October 2011 through 28 October 2011
ER -