Design of drug-delivery micro-wheel and auto-rolling control by change of gravity center

Jing Yao Lai, Nan Chyuan Tsai, Hsin Lin Chiu

Research output: Contribution to journalArticle

Abstract

A micro-dosing system of overall size 5×5×4.2 mm3 for drug delivery is proposed and presented. The drug delivery system mainly consists of a micro-wheel and a micro-drug release mechanism. The motion of the micro-wheel is controlled by its center of gravity via a running disk, which is placed within the hollow micro-wheel and attracted by the actuated micro-solenoids fabricated on the inner wall of micro-wheel in shift. In addition, the micro-wheel is controlled to roll forwards/backwards to the designated location by two sliding mode control strategies: one for long-distance motion (to transport the drug to the vicinity of the spots under disease) and the other for short-distance motion (to decelerate down and stop at the exact drug-release location). On the other hand, the microdrug release mechanism is composed by a cantilever beam and a chamber filled up by medicine. The pyramid tip of the cantilever beam deflected by the applied electrostatic force is designed to penetrate the micro-film which seals the chamber so that the medicine can be released at the specified spot.

Original languageEnglish
Pages (from-to)1359-1369
Number of pages11
JournalInternational Journal of Precision Engineering and Manufacturing
Volume15
Issue number7
DOIs
Publication statusPublished - 2014 Jul

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering
  • Electrical and Electronic Engineering

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