The main goal of this study is to design a full-car active suspension controller with a reduced order observer for vehicles so as to improve ride comfort and reduce the suspension deflection. The proposed fuzzy sliding-mode control (FSMC) consists of the sliding-mode control (SMC) and the fuzzy logic control (FLC), where the SMC can decrease the suspension deflection of the car and the FLC can improve the ride comfort of the passengers. The full-car model of an automobile is firstly examined in this paper. The stability property of the fuzzy sliding-mode controlled active suspension system is confirmed by the Lyapunov stability analysis. In order to make comparison, we also introduce the optimal active suspension control (OASC) scheme. Three kinds of road profiles, a bump road, a random white noise and a power spectral density road profile, are exploited to test the performance. All the computer simulations demonstrate that the proposed FSMC can provide the best ride comfort and the least suspension deflection among all the examined controllers under all these road profiles.