Designing a molecularly imprinted polymer as an artificial receptor for the specific recognition of creatinine in serums

Ryh Yaw Hsieh, Hsuan Ang Tsai, Mei-Jywan Syu

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

In this study, molecularly imprinted polymers (MIP) synthesized from two different functional monomers, β-cyclodextrin (β-CD) and 4-vinylpyridine (4-Vpy), were prepared. The crosslinkers used for these two monomers were epichlorohydrin (EPI) and divinylbenzene (DVB), respectively. It was attempted to adsorb the target molecule, creatinine, from its mixture solutions. A proper molar ratio of monomer/crosslinker for the preparation of the imprinted poly(β-CD) was 1:10. Between both polymers mentioned above, the affinity of the imprinted poly(4-Vpy-co-DVB) towards creatinine was comparably superior. The imprinted poly(4-Vpy-co-DVB) for creatinine could reach a specific binding ratio of 3.11. The imprinted poly(4-Vpy-co-DVB) was further utilized to bind creatinine from human serum samples. The binding capacity of the imprinted poly(4-Vpy-co-DVB) for creatinine from the serum samples was plotted against the creatinine concentration. From the correlation, the feasibility of the imprinted poly(4-Vpy-co-DVB) thus prepared for the target analyte, creatinine, was experimentally confirmed.

Original languageEnglish
Pages (from-to)2083-2089
Number of pages7
JournalBiomaterials
Volume27
Issue number9
DOIs
Publication statusPublished - 2006 Mar 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint Dive into the research topics of 'Designing a molecularly imprinted polymer as an artificial receptor for the specific recognition of creatinine in serums'. Together they form a unique fingerprint.

Cite this