Abstract
This paper proposes a sensor for glycated hemoglobin (HbA1c) detection based on impedance measurement. The sensor contains a pair of parallel facing electrodes integrated into a microfluidic device. A pair of parallel facing electrodes is fabricated to characterize the impedance change and determine the concentration of HbA 1c. A self-assembled monolayer (SAM) of thiophene-3-boronic acid (T3BA) is used for modifying the gold electrodes. Non-faradaic electrochemical detection of surface-bound HbA 1c with no redox indicator added is conducted by utilizing the capacitive property as a sensing signal. The performance of the HbA 1c sensor was investigated by impedance analyzer and the impedance changes approximately logarithmically with the concentration of HbA1c in the range of 10-100 ng/μL. The proposed detection method has potential for use in point-of-care diagnostics and can be used for the detection of various biomolecules.
| Original language | English |
|---|---|
| Pages (from-to) | 1222-1230 |
| Number of pages | 9 |
| Journal | Sensors and Actuators, B: Chemical |
| Volume | 171-172 |
| DOIs | |
| Publication status | Published - 2012 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Instrumentation
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry
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Detection of glycated hemoglobin (HbA 1c) based on impedance measurement with parallel electrodes integrated into a microfluidic device. / Chuang, Ya Chun; Lan, Kung Chieh; Hsieh, Ku Meng; Jang, Ling-Sheng; Chen, Ming Kun.
In: Sensors and Actuators, B: Chemical, Vol. 171-172, 01.08.2012, p. 1222-1230.Research output: Contribution to journal › Article
TY - JOUR
T1 - Detection of glycated hemoglobin (HbA 1c) based on impedance measurement with parallel electrodes integrated into a microfluidic device
AU - Chuang, Ya Chun
AU - Lan, Kung Chieh
AU - Hsieh, Ku Meng
AU - Jang, Ling-Sheng
AU - Chen, Ming Kun
PY - 2012/8/1
Y1 - 2012/8/1
N2 - This paper proposes a sensor for glycated hemoglobin (HbA1c) detection based on impedance measurement. The sensor contains a pair of parallel facing electrodes integrated into a microfluidic device. A pair of parallel facing electrodes is fabricated to characterize the impedance change and determine the concentration of HbA 1c. A self-assembled monolayer (SAM) of thiophene-3-boronic acid (T3BA) is used for modifying the gold electrodes. Non-faradaic electrochemical detection of surface-bound HbA 1c with no redox indicator added is conducted by utilizing the capacitive property as a sensing signal. The performance of the HbA 1c sensor was investigated by impedance analyzer and the impedance changes approximately logarithmically with the concentration of HbA1c in the range of 10-100 ng/μL. The proposed detection method has potential for use in point-of-care diagnostics and can be used for the detection of various biomolecules.
AB - This paper proposes a sensor for glycated hemoglobin (HbA1c) detection based on impedance measurement. The sensor contains a pair of parallel facing electrodes integrated into a microfluidic device. A pair of parallel facing electrodes is fabricated to characterize the impedance change and determine the concentration of HbA 1c. A self-assembled monolayer (SAM) of thiophene-3-boronic acid (T3BA) is used for modifying the gold electrodes. Non-faradaic electrochemical detection of surface-bound HbA 1c with no redox indicator added is conducted by utilizing the capacitive property as a sensing signal. The performance of the HbA 1c sensor was investigated by impedance analyzer and the impedance changes approximately logarithmically with the concentration of HbA1c in the range of 10-100 ng/μL. The proposed detection method has potential for use in point-of-care diagnostics and can be used for the detection of various biomolecules.
UR - http://www.scopus.com/inward/record.url?scp=84864288186&partnerID=8YFLogxK
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U2 - 10.1016/j.snb.2012.06.084
DO - 10.1016/j.snb.2012.06.084
M3 - Article
VL - 171-172
SP - 1222
EP - 1230
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
SN - 0925-4005
ER -