Detection of IL-20 and its receptors on psoriatic skin

Chi Chen Wei, Wei Yu Chen, Yo Ching Wang, Po Jen Chen, Julia Yu Yun Lee, Tak Wah Wong, Wen Chieh Chen, Jen Chin Wu, Guan Ying Chen, Ming Shi Chang, Yu Chih Lin

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Abstract

The aim of this study was to investigate the expression of interleukin-20 (IL-20) and its receptors on psoriatic skin by immunohistochemical analysis and to evaluate the correlation of CD8-positive T lymphocytes with epidermal proliferation. Overexpression of IL-20 and its receptors was detected in the keratinocytes of the lesional skin of psoriasis and spongiotic dermatitis. The expression pattern of IL-20 spreads throughout the whole layer of epidermis, while IL-19 was expressed in up to three or four layers suprabasally. The serum level of IL-20 in psoriatic patients was significantly lower than that in healthy controls. IL-20 upregulated KGF transcripts on CD8-positive T cells. We hypothesize that overexpression of IL-20 is correlated with keratinocyte proliferation that acts through their receptor complex expressed by keratinocytes themselves. Furthermore, IL-20 can stimulate CD8-positive lymphocytes to produce KGF, which may contribute to sustaining the hyperproliferative status of the keratinocytes.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalClinical Immunology
Volume117
Issue number1
DOIs
Publication statusPublished - 2005 Oct 1

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Wei, C. C., Chen, W. Y., Wang, Y. C., Chen, P. J., Lee, J. Y. Y., Wong, T. W., Chen, W. C., Wu, J. C., Chen, G. Y., Chang, M. S., & Lin, Y. C. (2005). Detection of IL-20 and its receptors on psoriatic skin. Clinical Immunology, 117(1), 65-72. https://doi.org/10.1016/j.clim.2005.06.012