TY - JOUR
T1 - Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in vascular lesions
T2 - A reliable diagnostic marker for Kaposi's sarcoma
AU - Jin, Ying Tai
AU - Tsai, Sen Tien
AU - Yan, Jing Jou
AU - Hsiao, Jern Hsian
AU - Lee, Yu Yun
AU - Su, Ih Jen
PY - 1996/3
Y1 - 1996/3
N2 - A new herpesvirus-like DNA sequence (KSHV) has been recently identified in Kaposi's sarcoma (KS) from patients with AIDS and non-AIDS patients. To verify the specificity of the association of this new viral DNA with KS, a total of 155 cases of benign and malignant vascular neoplasms sharing similar histogenesis of endothelial derivation were analyzed for the presence of this KSHV sequence using the published 330-233 primers by polymerase chain reaction (PCR). The results revealed that all 17 cases of KS, both AIDS and non-AIDS, were positive for this KSHV, whereas the remaining 138 cases of vascular lesions other than KS, including 15 cases of angiosarcoma, showed negative reaction. These results confirm and extend the previous observation that this KSHV sequence is specifically associated with KS and is a reliable diagnostic marker to distinguish KS, particularly at its early stage, from other vascular lesions.
AB - A new herpesvirus-like DNA sequence (KSHV) has been recently identified in Kaposi's sarcoma (KS) from patients with AIDS and non-AIDS patients. To verify the specificity of the association of this new viral DNA with KS, a total of 155 cases of benign and malignant vascular neoplasms sharing similar histogenesis of endothelial derivation were analyzed for the presence of this KSHV sequence using the published 330-233 primers by polymerase chain reaction (PCR). The results revealed that all 17 cases of KS, both AIDS and non-AIDS, were positive for this KSHV, whereas the remaining 138 cases of vascular lesions other than KS, including 15 cases of angiosarcoma, showed negative reaction. These results confirm and extend the previous observation that this KSHV sequence is specifically associated with KS and is a reliable diagnostic marker to distinguish KS, particularly at its early stage, from other vascular lesions.
UR - https://www.scopus.com/pages/publications/0029968291
UR - https://www.scopus.com/pages/publications/0029968291#tab=citedBy
U2 - 10.1093/ajcp/105.3.360
DO - 10.1093/ajcp/105.3.360
M3 - Article
C2 - 8602618
AN - SCOPUS:0029968291
SN - 0002-9173
VL - 105
SP - 360
EP - 363
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 3
ER -