TY - GEN
T1 - Detection of transient ischemia and hemorrhage in blood-brain barrierdisruption by high-frequency ultrasound imaging
AU - Ting, Chien Yu
AU - Fan, Ching Hsiang
AU - Yeh, Chih Kuang
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Focused ultrasound (FUS) with microbubbles has been discovered to locallyincrease the permeability of blood-brain barrier (BBB). However, bioeffects suchas erythrocyte extravasations and brain tissue damage may accompany. Therefore,development of a real-time imaging method to visualize occurrence of braininjury during opening of BBB by FUS is chief to improve the safety of thistechnology. The purpose of this study is to investigate the feasibility of usingthe high-frequency ultrasound imaging technique including contrast-enhanced andB-mode two images to monitor the transient responses of BBB disruption (BBBD)induced by FUS. We observed that BBBD with extensive hemorrhage and ischemia in1-MHz FUS with 1.1 MPa. The bright spots from the blood clots scatteringappeared in B-mode images and correspond to the map without perfusion in thecontrast-enhanced images. In addition, a relative safe power to BBBD withoutsuch bioeffects was 0.3 MPa. The results indicated that location of hyperechoicspots correlates with hemorrhage areas and the ischemia region consistent withthe BBBD areas under the cases of high FUS power. That reflected high-frequencyultrasound can provide the information of microhemorrhage and transient ischemiainformation during BBB open by FUS.
AB - Focused ultrasound (FUS) with microbubbles has been discovered to locallyincrease the permeability of blood-brain barrier (BBB). However, bioeffects suchas erythrocyte extravasations and brain tissue damage may accompany. Therefore,development of a real-time imaging method to visualize occurrence of braininjury during opening of BBB by FUS is chief to improve the safety of thistechnology. The purpose of this study is to investigate the feasibility of usingthe high-frequency ultrasound imaging technique including contrast-enhanced andB-mode two images to monitor the transient responses of BBB disruption (BBBD)induced by FUS. We observed that BBBD with extensive hemorrhage and ischemia in1-MHz FUS with 1.1 MPa. The bright spots from the blood clots scatteringappeared in B-mode images and correspond to the map without perfusion in thecontrast-enhanced images. In addition, a relative safe power to BBBD withoutsuch bioeffects was 0.3 MPa. The results indicated that location of hyperechoicspots correlates with hemorrhage areas and the ischemia region consistent withthe BBBD areas under the cases of high FUS power. That reflected high-frequencyultrasound can provide the information of microhemorrhage and transient ischemiainformation during BBB open by FUS.
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U2 - 10.1109/ULTSYM.2010.5935913
DO - 10.1109/ULTSYM.2010.5935913
M3 - Conference contribution
AN - SCOPUS:80054053180
SN - 9781457703829
T3 - Proceedings - IEEE Ultrasonics Symposium
SP - 1578
EP - 1581
BT - 2010 IEEE International Ultrasonics Symposium, IUS 2010
T2 - 2010 IEEE International Ultrasonics Symposium, IUS 2010
Y2 - 11 October 2010 through 14 October 2010
ER -