Determination and disposition kinetics of phellamurin metabolites in rat brain

Hung Yi Chen, Tian Shung Wu, Yu Chi Hou, Sheng Chu Kuo, Pei Dawn Lee Chao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Phellamurin is a flavanone glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). The disposition kinetics of phellamurin metabolites in rat brain was investigated in this study. Doses of 100 mg/kg and 200 mg/kg were orally administered to rats. At 0.33, 2, 4 and 6 hr after dosing, rats were dissected and the brain concentrations of the aglycone neophellamuretin were determined by an HPLC method prior to and after hydrolysis with β-glucuronidase. The mobile phase was acetonitrile: H 2O (containing 1 % acetic acid, 38:62, v/v). Our results indicated that neophellamuretin glucuronide might be able to cross the blood-brain barrier and its concentration in the brain was dose-dependent at the two doses investigated, whereas the aglycone neophellamuretin was present in a trace amount in the brain.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of Food and Drug Analysis
Volume9
Issue number3
Publication statusPublished - 2001 Dec 1

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

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