An optical tweezers system has been adopted for molecular biomechanical testing. To achieve nanometer manipulation and measurement, the system was modified with a piezo-stage and an interferometer. A systematic calibration was then performed on the displacement resolution. The results revealed that the system has a nanometer resolution which is sufficient for the measurement of deformation and stiffness of single macro-molecules.
|Number of pages
|American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
|Published - 1998
All Science Journal Classification (ASJC) codes
- General Engineering