In this paper, a portable real-time wireless embedded brain signal acquisition/processing system is developed. The proposed system integrates electroencephalogram signal amplifier technique, wireless transmission technique, and embedded real-time system. The development strategy of this system contains three parts: First, the Bluetooth protocol is used as a transmission interface and integrated with the bio-signal amplifier to transmit the measured physiological signals wirelessly. Second, the OMAP (Open Multimedia Architecture Platform) is used as a development platform and an embedded operating system for OMAP is also designed. Finally, DSP Gateway is developed as a mechanism to deal with the brain-signal analyzing tasks shared by ARM and DSP. A driver's cognitive-state estimation program has been developed and implemented on the proposed dual core processor-based real time wireless embedded system for demonstration.