Development of hyperthyroidism following primary hypothyroidism: A case report

Yueh Hua Chung, Horng Yih Ou, Ta Jen Wu

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5 Citations (Scopus)


Development of hyperthyroidism following primary hypothyroidism is uncommon, and only a few documented cases have been reported. Alterations in thyroid-stimulating hormone receptor antibodies in serum are currently considered to play the main role in the pathophysiology, but the exact mechanism is still unknown. Here, we report the case of a 60-year-old man with disturbed consciousness due to hyponatremia. Thyroid function tests showed primary hypothyroidism with a high anti-microsomal antibody titer (1:6,400). The patient experienced weight loss and exophthalmos 6 years later. Serum thyroid hormone levels were increased and thyroxine treatment was discontinued, but the patient remained thyrotoxic 2 months later. 131I thyroid uptake was 40.9% at 24 hours, and bilateral thyroid lobes were not enlarged with diffuse radioactivity. Six months later, the patient was still thyrotoxic and therapy with methimazole 10 mg/day was started. He is now taking methimazole and is euthyroid.

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalKaohsiung Journal of Medical Sciences
Issue number4
Publication statusPublished - 2004 Apr

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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