Development of hyperthyroidism following primary hypothyroidism: A case report

Yueh Hua Chung, Horng-Yih Ou, Ta Jen Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Development of hyperthyroidism following primary hypothyroidism is uncommon, and only a few documented cases have been reported. Alterations in thyroid-stimulating hormone receptor antibodies in serum are currently considered to play the main role in the pathophysiology, but the exact mechanism is still unknown. Here, we report the case of a 60-year-old man with disturbed consciousness due to hyponatremia. Thyroid function tests showed primary hypothyroidism with a high anti-microsomal antibody titer (1:6,400). The patient experienced weight loss and exophthalmos 6 years later. Serum thyroid hormone levels were increased and thyroxine treatment was discontinued, but the patient remained thyrotoxic 2 months later. 131I thyroid uptake was 40.9% at 24 hours, and bilateral thyroid lobes were not enlarged with diffuse radioactivity. Six months later, the patient was still thyrotoxic and therapy with methimazole 10 mg/day was started. He is now taking methimazole and is euthyroid.

Original languageEnglish
Pages (from-to)188-191
Number of pages4
JournalKaohsiung Journal of Medical Sciences
Volume20
Issue number4
Publication statusPublished - 2004 Apr 1

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Hyperthyroidism
Hypothyroidism
Methimazole
Thyroid Gland
Thyroid Function Tests
Thyrotropin Receptors
Exophthalmos
Hyponatremia
Serum
Consciousness
Thyroxine
Thyroid Hormones
Radioactivity
Weight Loss
Anti-Idiotypic Antibodies
Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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Development of hyperthyroidism following primary hypothyroidism : A case report. / Chung, Yueh Hua; Ou, Horng-Yih; Wu, Ta Jen.

In: Kaohsiung Journal of Medical Sciences, Vol. 20, No. 4, 01.04.2004, p. 188-191.

Research output: Contribution to journalArticle

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