Development of specific aptamers with different histological classified ovarian cancer cells by utilizing on-chip OvCa cell-selex

Lien Yu Hung, Chih Hung Wang, Keng-Fu Hsu, Cheng-Yang Chou, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ovarian cancer is the second most common type of gynecological cancers. Comparing with the worst gynecological cancer, cervical cancer, the prognostication of ovarian cancer is relatively poor. It is challenging to diagnose it in the early stage where proper treatments are most effective. In order to achieve early detection of ovarian cancer, biomarkers with high specificity and affinity is therefore important. In this study, an integrated microfluidic system was developed for the multiple-cell-line and high-throughput screening of OvCa cell-SELEX automatically. An aptamer specific to ovarian cancer cells were successfully screened.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages368-370
Number of pages3
Volume1
ISBN (Print)9781632666246
Publication statusPublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: 2013 Oct 272013 Oct 31

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period13-10-2713-10-31

All Science Journal Classification (ASJC) codes

  • Bioengineering

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  • Cite this

    Hung, L. Y., Wang, C. H., Hsu, K-F., Chou, C-Y., & Lee, G. B. (2013). Development of specific aptamers with different histological classified ovarian cancer cells by utilizing on-chip OvCa cell-selex. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (Vol. 1, pp. 368-370). Chemical and Biological Microsystems Society.