Developments and applications of functional protein microarrays

Guan Da Syu, Jessica Dunn, Heng Zhu

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)


Protein microarrays are crucial tools in the study of proteins in an unbiased, high-throughput manner, as they allow for characterization of up to thousands of individually purified proteins in parallel. The adaptability of this technology has enabled its use in a wide variety of applications, including the study of proteome-wide molecular interactions, analysis of post-translational modifications, identification of novel drug targets, and examination of pathogen-host interactions. In addition, the technology has also been shown to be useful in profiling antibody specificity, as well as in the discovery of novel biomarkers, especially for autoimmune diseases and cancers. In this review, we will summarize the developments that have been made in protein microarray technology in both in basic and translational research over the past decade. We will also introduce a novel membrane protein array, the GPCR-VirD array, and discuss the future directions of functional protein microarrays.

Original languageEnglish
Pages (from-to)916-927
Number of pages12
JournalMolecular and Cellular Proteomics
Issue number6
Publication statusPublished - 2020 Jun

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Molecular Biology


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