TY - JOUR
T1 - Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel
T2 - A potential model to study carpal tunnel syndrome?
AU - Oh, Sangho
AU - Ettema, Anke M.
AU - Zhao, Chunfeng
AU - Zobitz, Mark E.
AU - Wold, Lester E.
AU - An, Kai Nan
AU - Amadio, Peter C.
N1 - Funding Information:
Acknowledgement This study was funded by grants from NIH (AR49823) and Mayo Foundation.
PY - 2008/3
Y1 - 2008/3
N2 - In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.
AB - In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.
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U2 - 10.1007/s11552-007-9058-y
DO - 10.1007/s11552-007-9058-y
M3 - Article
C2 - 18780118
AN - SCOPUS:39049089166
SN - 1558-9447
VL - 3
SP - 34
EP - 40
JO - Hand
JF - Hand
IS - 1
ER -