Diagnosis of gastric malignancy using gastric juice α1-antitrypsin

Ping I. Hsu, Chung Hsuan Chen, Michael Hsiao, Deng Chyang Wu, Ching Yi Lin, Kwok Hung Lai, Pei Jung Lu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

No accurate, inexpensive, and noninvasive test for gastric cancer screening is currently available. Our recent study identified α1-antitrypsin as a potential biomarker of gastric cancer in gastric juice. The aim of this study was to develop a novel noninvasive modality for detecting gastric cancer by measurement of α1-antitrypsin concentration in gastric juice. The work consisted of two parts: (a) investigating the differences in gastric juice α1-antitrypsin concentrations between gastric cancer patients and controls, and (b) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for α1-antitrypsin concentration. The data showed that gastric juice α1-antitrypsin concentration was markedly higher in gastric cancer patients than in healthy subjects, gastric ulcer patients, and duodenal ulcer patients (all P < 0.001). The area under the receiver operating characteristic curve for identifying gastric cancer cases was 0.96 (95% confidence interval, 0.93-0.99; P < 0.001). The sensitivity and specificity of gastric juice α1-antitrypsin concentration were 96% and 92%, respectively. Gastric juice α1-antitrypsin assay through string test was validated in 93 consecutive patients for gastric cancer screening. The sensitivity and specificity of gastric juice α1-antitrypsin string test at 85% accuracy were 74% and 88%, respectively. The area under the receiver operating characteristic curve for identifying gastric cancer was 0.84. In conclusion, gastric juice α1-antitrypsin concentration in gastric cancer patients markedly exceeds those in healthy subjects and patients with benign gastrointestinal diseases. A noninvasive α1-antitrypsin string test may serve as a new screening tool for identifying gastric cancer patients.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

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