Diagnosis of gastric malignancy using gastric juice α1-antitrypsin

Ping I. Hsu, Chung Hsuan Chen, Michael Hsiao, Deng Chyang Wu, Ching Yi Lin, Kwok Hung Lai, Pei-Jung Lu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

No accurate, inexpensive, and noninvasive test for gastric cancer screening is currently available. Our recent study identified α1-antitrypsin as a potential biomarker of gastric cancer in gastric juice. The aim of this study was to develop a novel noninvasive modality for detecting gastric cancer by measurement of α1-antitrypsin concentration in gastric juice. The work consisted of two parts: (a) investigating the differences in gastric juice α1-antitrypsin concentrations between gastric cancer patients and controls, and (b) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for α1-antitrypsin concentration. The data showed that gastric juice α1-antitrypsin concentration was markedly higher in gastric cancer patients than in healthy subjects, gastric ulcer patients, and duodenal ulcer patients (all P < 0.001). The area under the receiver operating characteristic curve for identifying gastric cancer cases was 0.96 (95% confidence interval, 0.93-0.99; P < 0.001). The sensitivity and specificity of gastric juice α1-antitrypsin concentration were 96% and 92%, respectively. Gastric juice α1-antitrypsin assay through string test was validated in 93 consecutive patients for gastric cancer screening. The sensitivity and specificity of gastric juice α1-antitrypsin string test at 85% accuracy were 74% and 88%, respectively. The area under the receiver operating characteristic curve for identifying gastric cancer was 0.84. In conclusion, gastric juice α1-antitrypsin concentration in gastric cancer patients markedly exceeds those in healthy subjects and patients with benign gastrointestinal diseases. A noninvasive α1-antitrypsin string test may serve as a new screening tool for identifying gastric cancer patients.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

Fingerprint

Gastric Juice
Stomach Neoplasms
Stomach
Neoplasms
Early Detection of Cancer
ROC Curve
Healthy Volunteers
Sensitivity and Specificity
Gastrointestinal Diseases
Stomach Ulcer
Duodenal Ulcer
Immunoassay
Biomarkers

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Hsu, Ping I. ; Chen, Chung Hsuan ; Hsiao, Michael ; Wu, Deng Chyang ; Lin, Ching Yi ; Lai, Kwok Hung ; Lu, Pei-Jung. / Diagnosis of gastric malignancy using gastric juice α1-antitrypsin. In: Cancer Epidemiology Biomarkers and Prevention. 2010 ; Vol. 19, No. 2. pp. 405-411.
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abstract = "No accurate, inexpensive, and noninvasive test for gastric cancer screening is currently available. Our recent study identified α1-antitrypsin as a potential biomarker of gastric cancer in gastric juice. The aim of this study was to develop a novel noninvasive modality for detecting gastric cancer by measurement of α1-antitrypsin concentration in gastric juice. The work consisted of two parts: (a) investigating the differences in gastric juice α1-antitrypsin concentrations between gastric cancer patients and controls, and (b) screening gastric cancer using string test to obtain gastric juice followed by immunoassay for α1-antitrypsin concentration. The data showed that gastric juice α1-antitrypsin concentration was markedly higher in gastric cancer patients than in healthy subjects, gastric ulcer patients, and duodenal ulcer patients (all P < 0.001). The area under the receiver operating characteristic curve for identifying gastric cancer cases was 0.96 (95{\%} confidence interval, 0.93-0.99; P < 0.001). The sensitivity and specificity of gastric juice α1-antitrypsin concentration were 96{\%} and 92{\%}, respectively. Gastric juice α1-antitrypsin assay through string test was validated in 93 consecutive patients for gastric cancer screening. The sensitivity and specificity of gastric juice α1-antitrypsin string test at 85{\%} accuracy were 74{\%} and 88{\%}, respectively. The area under the receiver operating characteristic curve for identifying gastric cancer was 0.84. In conclusion, gastric juice α1-antitrypsin concentration in gastric cancer patients markedly exceeds those in healthy subjects and patients with benign gastrointestinal diseases. A noninvasive α1-antitrypsin string test may serve as a new screening tool for identifying gastric cancer patients.",
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Diagnosis of gastric malignancy using gastric juice α1-antitrypsin. / Hsu, Ping I.; Chen, Chung Hsuan; Hsiao, Michael; Wu, Deng Chyang; Lin, Ching Yi; Lai, Kwok Hung; Lu, Pei-Jung.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 19, No. 2, 01.02.2010, p. 405-411.

Research output: Contribution to journalArticle

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AU - Hsu, Ping I.

AU - Chen, Chung Hsuan

AU - Hsiao, Michael

AU - Wu, Deng Chyang

AU - Lin, Ching Yi

AU - Lai, Kwok Hung

AU - Lu, Pei-Jung

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