Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT

Tsu Chi Cheng, Nan-Tsing Chiu, Ting Yu Su, Yi Fei He, Wei Tse Yang, Yu-Hua Dean Fang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lung Cancer is a leading cause of death worldwide, and about 85% of lung cancer is non-small cell lung cancer (NSCLC). The staging of lymph nodes in NSCLC patients is extremely important because respective stages require different treatments. FDG-PET/CT is a gold standard for lymph node metastasis staging of NSCLC. However, the results of discriminating lymph node staging on 18F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) / computed tomography (CT) still needs improvement. In addition to the traditional image parameters of FDG-PET/CT such as standardized uptake value (SUV), there are many other parameters available from FDG-PET/CT images, for example, the lymphatic drainage pathway. Other than this, texture analysis which distinguishes subtle difference can also be a way to define lymph node staging. For the purpose of a better accuracy on lymph node metastasis diagnosis on NSCLC patient in FDG-PET/CT, this research developed a computer-aided diagnosis (CAD) system to improve the diagnostic efficiency, which achieved 88.056% accuracy.

Original languageEnglish
Title of host publicationInternational Forum on Medical Imaging in Asia 2019
EditorsJong Hyo Kim, Hiroshi Fujita, Feng Lin
PublisherSPIE
ISBN (Electronic)9781510627758
DOIs
Publication statusPublished - 2019 Jan 1
EventInternational Forum on Medical Imaging in Asia 2019 - Singapore, Singapore
Duration: 2019 Jan 72019 Jan 9

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11050
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceInternational Forum on Medical Imaging in Asia 2019
CountrySingapore
CitySingapore
Period19-01-0719-01-09

Fingerprint

Positron Emission Tomography
Positron emission tomography
Metastasis
lymphatic system
Lung Cancer
Computed Tomography
metastasis
Glucose
glucose
lungs
Tomography
positrons
tomography
cancer
Cells
Cell
Vertex of a graph
Computer aided diagnosis
Computer-aided Diagnosis
Texture Analysis

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Cheng, T. C., Chiu, N-T., Su, T. Y., He, Y. F., Yang, W. T., & Fang, Y-H. D. (2019). Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT. In J. H. Kim, H. Fujita, & F. Lin (Eds.), International Forum on Medical Imaging in Asia 2019 [110500Z] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11050). SPIE. https://doi.org/10.1117/12.2521510
Cheng, Tsu Chi ; Chiu, Nan-Tsing ; Su, Ting Yu ; He, Yi Fei ; Yang, Wei Tse ; Fang, Yu-Hua Dean. / Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT. International Forum on Medical Imaging in Asia 2019. editor / Jong Hyo Kim ; Hiroshi Fujita ; Feng Lin. SPIE, 2019. (Proceedings of SPIE - The International Society for Optical Engineering).
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title = "Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT",
abstract = "Lung Cancer is a leading cause of death worldwide, and about 85{\%} of lung cancer is non-small cell lung cancer (NSCLC). The staging of lymph nodes in NSCLC patients is extremely important because respective stages require different treatments. FDG-PET/CT is a gold standard for lymph node metastasis staging of NSCLC. However, the results of discriminating lymph node staging on 18F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) / computed tomography (CT) still needs improvement. In addition to the traditional image parameters of FDG-PET/CT such as standardized uptake value (SUV), there are many other parameters available from FDG-PET/CT images, for example, the lymphatic drainage pathway. Other than this, texture analysis which distinguishes subtle difference can also be a way to define lymph node staging. For the purpose of a better accuracy on lymph node metastasis diagnosis on NSCLC patient in FDG-PET/CT, this research developed a computer-aided diagnosis (CAD) system to improve the diagnostic efficiency, which achieved 88.056{\%} accuracy.",
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Cheng, TC, Chiu, N-T, Su, TY, He, YF, Yang, WT & Fang, Y-HD 2019, Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT. in JH Kim, H Fujita & F Lin (eds), International Forum on Medical Imaging in Asia 2019., 110500Z, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11050, SPIE, International Forum on Medical Imaging in Asia 2019, Singapore, Singapore, 19-01-07. https://doi.org/10.1117/12.2521510

Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT. / Cheng, Tsu Chi; Chiu, Nan-Tsing; Su, Ting Yu; He, Yi Fei; Yang, Wei Tse; Fang, Yu-Hua Dean.

International Forum on Medical Imaging in Asia 2019. ed. / Jong Hyo Kim; Hiroshi Fujita; Feng Lin. SPIE, 2019. 110500Z (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11050).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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N2 - Lung Cancer is a leading cause of death worldwide, and about 85% of lung cancer is non-small cell lung cancer (NSCLC). The staging of lymph nodes in NSCLC patients is extremely important because respective stages require different treatments. FDG-PET/CT is a gold standard for lymph node metastasis staging of NSCLC. However, the results of discriminating lymph node staging on 18F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) / computed tomography (CT) still needs improvement. In addition to the traditional image parameters of FDG-PET/CT such as standardized uptake value (SUV), there are many other parameters available from FDG-PET/CT images, for example, the lymphatic drainage pathway. Other than this, texture analysis which distinguishes subtle difference can also be a way to define lymph node staging. For the purpose of a better accuracy on lymph node metastasis diagnosis on NSCLC patient in FDG-PET/CT, this research developed a computer-aided diagnosis (CAD) system to improve the diagnostic efficiency, which achieved 88.056% accuracy.

AB - Lung Cancer is a leading cause of death worldwide, and about 85% of lung cancer is non-small cell lung cancer (NSCLC). The staging of lymph nodes in NSCLC patients is extremely important because respective stages require different treatments. FDG-PET/CT is a gold standard for lymph node metastasis staging of NSCLC. However, the results of discriminating lymph node staging on 18F-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) / computed tomography (CT) still needs improvement. In addition to the traditional image parameters of FDG-PET/CT such as standardized uptake value (SUV), there are many other parameters available from FDG-PET/CT images, for example, the lymphatic drainage pathway. Other than this, texture analysis which distinguishes subtle difference can also be a way to define lymph node staging. For the purpose of a better accuracy on lymph node metastasis diagnosis on NSCLC patient in FDG-PET/CT, this research developed a computer-aided diagnosis (CAD) system to improve the diagnostic efficiency, which achieved 88.056% accuracy.

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A2 - Kim, Jong Hyo

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A2 - Lin, Feng

PB - SPIE

ER -

Cheng TC, Chiu N-T, Su TY, He YF, Yang WT, Fang Y-HD. Diagnosis of lymph node metastasis in non-small-cell lung cancer (NSCLC) patient on F-18-FDG PET/CT. In Kim JH, Fujita H, Lin F, editors, International Forum on Medical Imaging in Asia 2019. SPIE. 2019. 110500Z. (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.2521510