Dichotomy of the function of DDR1 in cells and disease progression

Yi Chun Yeh, Hsi Hui Lin, Ming-Jer Tang

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Discoidin domain receptors DDR1 and DDR2 are collagen receptor tyrosine kinases that have many roles in tissue development and disease progression. Under physiological conditions, DDR1 is predominantly expressed in epithelial cells and functions to maintain cell differentiation and tissue homeostasis. A switch in expression from DDR1 to DDR2 occurs during epithelial-to-mesenchymal transition. However, opposite effects of DDR1 are reported to be involved in the progression of cancer and fibrotic diseases. Accumulating evidence suggests that DDR1 is involved in pro-metastasis and pro-survival signals. This review summarizes the roles of DDR1 in epithelial cell differentiation, cell migration, cancer progression and tissues fibrosis and highlights how the dichotomous functions of DDR1 may relevant to different cell types and statues. Elucidation of the underlying mechanism of the dichotomous functions of DDR1 will help to develop DDR1 as a therapeutic target.

Original languageEnglish
Article number118473
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1866
Issue number11
DOIs
Publication statusPublished - 2019 Nov 1

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Disease Progression
Cell Differentiation
Epithelial Cells
Collagen Receptors
Epithelial-Mesenchymal Transition
Protein-Tyrosine Kinases
Cell Movement
Neoplasms
Homeostasis
Fibrosis
Neoplasm Metastasis
Therapeutics
Discoidin Domain Receptors

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

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Dichotomy of the function of DDR1 in cells and disease progression. / Yeh, Yi Chun; Lin, Hsi Hui; Tang, Ming-Jer.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1866, No. 11, 118473, 01.11.2019.

Research output: Contribution to journalReview article

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