Different functional gene clusters in yeast have different spatial distributions of the transcription factor binding sites

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Transcription factors control gene expression by binding to short specific DNA sequences, called transcription factor binding sites (TFBSs), in the promoter of a gene. Thus, studying the spatial distribution of TFBSs in the promoters may provide insights into the molecular mechanisms of gene regulation. I developed a method to construct the spatial distribution of TFBSs for any set of genes of interest. I found that different functional gene clusters have different spatial distributions of TFBSs, indicating that gene regulation mechanisms may be very different among different functional gene clusters. I also found that the binding sites for different transcription factors (TFs) may have different spatial distributions: A sharp peak, a plateau or no dominant single peak. The spatial distributions of binding sites for many TFs derived from my analyses are valuable prior information for TFBS prediction algorithm because different regions of a promoter can assign different possibilities for TFBS occurrence.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBioinformatics and Biology Insights
Volume5
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Mathematics
  • Applied Mathematics

Fingerprint Dive into the research topics of 'Different functional gene clusters in yeast have different spatial distributions of the transcription factor binding sites'. Together they form a unique fingerprint.

Cite this