Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing

Yu Ting Tsao, Yao Hung Tsai, Wan Ting Liao, Ching Ju Shen, Ching Fen Shen, Chao Min Cheng

Research output: Contribution to journalReview articlepeer-review

Abstract

Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indications for antibiotic treatment. This article reviews potential protein biomarkers and host-derived gene expression signatures for differentiating between bacterial and viral infections in children, and focuses on emerging multiplex POCT devices for the simultaneous detection of sets of protein biomarkers or streamlined gene expression signatures that may provide rapid and cost-effective pathogen-discriminating tools.

Original languageEnglish
JournalTrends in Molecular Medicine
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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