Differential miR-346 and miR-582-3p expression in association with selected maternal and fetal complications

Py Tsai, Sheng-Hsiang Lin, Wan Ni Chen, Hui Ling Tsai, Mei-Tsz Su

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5 Citations (Scopus)

Abstract

Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including healthy control (n = 60), preeclampsia (n = 31), preterm delivery (n = 29) and small for gestational age (n = 19) patients. The expression levels of miR-346 and miR-582-3p in all included adverse obstetric outcome groups were significantly higher in the maternal plasma samples but lower in the placenta samples (all p value < 0.05). In addition, the miR-346 expression levels in fetal cord blood were also significantly lower in all of the included adverse obstetric outcome groups (all p < 0.05). Multivariate analysis of the three specimens after adjusting for maternal age and gestational age at delivery gave the same results. In conclusion, aberrant miR-346 and miR-582-3p expression level in pregnancy was associated with multiple maternal and fetal complications. Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes.

Original languageEnglish
Article number1570
JournalInternational journal of molecular sciences
Volume18
Issue number7
DOIs
Publication statusPublished - 2017 Jul 19

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Obstetrics
Fetal Blood
blood
Blood
Mothers
Association reactions
Placenta
MicroRNAs
Gestational Age
pregnancy
delivery
Maternal Age
Pregnancy Outcome
Pre-Eclampsia
biomarkers
Pregnant Women
Biomarkers
Multivariate Analysis
Pregnancy
adjusting

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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title = "Differential miR-346 and miR-582-3p expression in association with selected maternal and fetal complications",
abstract = "Several miRNAs are expressed in human gestational tissue, and some have been shown to be associated with placental dysfunction and complicated pregnancy outcomes. To investigate the roles of miR-346 and miR-582-3p in adverse obstetric events, we analyzed these 2 miRNAs in three samples (maternal blood, umbilical cord blood and placenta) obtained from pregnant women in four groups, including healthy control (n = 60), preeclampsia (n = 31), preterm delivery (n = 29) and small for gestational age (n = 19) patients. The expression levels of miR-346 and miR-582-3p in all included adverse obstetric outcome groups were significantly higher in the maternal plasma samples but lower in the placenta samples (all p value < 0.05). In addition, the miR-346 expression levels in fetal cord blood were also significantly lower in all of the included adverse obstetric outcome groups (all p < 0.05). Multivariate analysis of the three specimens after adjusting for maternal age and gestational age at delivery gave the same results. In conclusion, aberrant miR-346 and miR-582-3p expression level in pregnancy was associated with multiple maternal and fetal complications. Their differential expression in maternal blood, umbilical cord blood and placenta could be potential biomarkers or therapeutic targets for adverse obstetric outcomes.",
author = "Py Tsai and Sheng-Hsiang Lin and Chen, {Wan Ni} and Tsai, {Hui Ling} and Mei-Tsz Su",
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AU - Tsai, Hui Ling

AU - Su, Mei-Tsz

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