TY - JOUR
T1 - Diffusion-weighted imaging as an aid in the diagnosis of the etiology of medial longitudinal fasciculus syndrome
AU - Chuang, Ming Tsung
AU - Lin, Chou Ching
AU - Sung, Pi Shan
AU - Su, Hui Chen
AU - Chen, Ying Chen
AU - Liu, Yi Sheng
N1 - Funding Information:
Acknowledgments this study was supported by a grant from national cheng Kung University Hospital (ncKUH-9902052).
PY - 2014/9
Y1 - 2014/9
N2 - Purpose: Internuclear ophthalmoplegia is caused by a lesion; stroke, multiple sclerosis, brain metastases, or trauma may produce lesions of the medial longitudinal fasciculus (MLF). Imaging techniques, such as DWI, can help identify the site of the lesion in order to speed diagnosis and lead to appropriate treatment. Methods: Over an 8-month period, eight consecutive patients with suspected MLF syndrome (most secondary to ischemic stroke) underwent MRI examinations, including DWI sequencing, at an academic center in Taiwan. Results: In all eight patients, abnormal high-signal lesions were found close to the floor of the fourth ventricle on the dorsal side of the pons. A neuroanatomical comparison showed that the location of the lesions was identical to the anatomical position of the MLF. Conclusion: Using DWI, good clinico-radiological correlation was found in all eight ischemic stroke patients diagnosed with MLF syndrome. DWI may broaden the application of MRI in the diagnosis of MLF syndrome.
AB - Purpose: Internuclear ophthalmoplegia is caused by a lesion; stroke, multiple sclerosis, brain metastases, or trauma may produce lesions of the medial longitudinal fasciculus (MLF). Imaging techniques, such as DWI, can help identify the site of the lesion in order to speed diagnosis and lead to appropriate treatment. Methods: Over an 8-month period, eight consecutive patients with suspected MLF syndrome (most secondary to ischemic stroke) underwent MRI examinations, including DWI sequencing, at an academic center in Taiwan. Results: In all eight patients, abnormal high-signal lesions were found close to the floor of the fourth ventricle on the dorsal side of the pons. A neuroanatomical comparison showed that the location of the lesions was identical to the anatomical position of the MLF. Conclusion: Using DWI, good clinico-radiological correlation was found in all eight ischemic stroke patients diagnosed with MLF syndrome. DWI may broaden the application of MRI in the diagnosis of MLF syndrome.
UR - http://www.scopus.com/inward/record.url?scp=84906939535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906939535&partnerID=8YFLogxK
U2 - 10.1007/s00276-014-1256-z
DO - 10.1007/s00276-014-1256-z
M3 - Article
C2 - 24464290
AN - SCOPUS:84906939535
SN - 0930-1038
VL - 36
SP - 675
EP - 680
JO - Surgical and Radiologic Anatomy
JF - Surgical and Radiologic Anatomy
IS - 7
ER -